If you want to use GPUs for computations, I suggest that you take a look at
CUDA
(http://www.nvidia.com/cuda). The SDK is available for free and it is
using a C like syntax (so you don't need to write shader and be
familiar with OpenGL or DX9 ).
there's ATI/AMD's CTM effort as well, as well as several independent ones.
www.gpgpu.org is a great resource to start with.
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