We also just had this same "421 Misdirected Request" error on all the
sites we hosted after unattended-upgrades auto updated this morning.
Rolling back to previous version resolved for now.

Checking the apache error logs per site we say the following:

> [Thu Jul 17 06:45:16.091474 2025] [ssl:error] [pid 2051895:tid
139659384452800] [client X.X.X.X:0] AH02032: Hostname
000-default.site.com (default host as no SNI was provided) and hostname
www.site.co.uk provided via HTTP have no compatible SSL setup

Requests to each site (e.g. www.site.co.uk used as example above) apache
would appear to be using the default site's SSL instead of their per
site SSL.

Ref the comment about plesk, we don't use plesk btw, no management app
like that, we have apache2 installed directly on ubuntu 24.04.

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https://bugs.launchpad.net/bugs/2117112

Title:
  421 Misdirected Request

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