it is plesk related:
https://support.plesk.com/hc/en-us/articles/33500191748887-Websites-hosted-in-Plesk-are-not-accessible-after-a-recent-Apache-update-421-Misdirected-Request

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https://bugs.launchpad.net/bugs/2117112

Title:
  421 Misdirected Request

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