I was able to reproduce this issue, and the problem is that wpa_supplicant is unable to bring the interface up after boot:
/var/log/syslog: 7027 May 22 23:11:17 evapro wpa_supplicant[1628]: Could not set interface wlx048d38ab601a flags (UP): Operation not permitted 7028 May 22 23:11:17 evapro wpa_supplicant[1628]: nl80211: Could not set interface 'wlx048d38ab601a' UP 7029 May 22 23:11:17 evapro wpa_supplicant[1628]: nl80211: deinit ifname=wlx048d38ab601a disabled_11b_rates=0 7030 May 22 23:11:17 evapro wpa_supplicant[1628]: Could not set interface wlx048d38ab601a flags (UP): Operation not permitted 7031 May 22 23:11:17 evapro wpa_supplicant[1628]: WEXT: Could not set interface 'wlx048d38ab601a' UP 7032 May 22 23:11:17 evapro wpa_supplicant[1628]: wlx048d38ab601a: Failed to initialize driver interface rsalveti@evapro:~$ sudo ifconfig wlx048d38ab601a up SIOCSIFFLAGS: Operation not permitted Worked fine after usb unplug/plug. -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1509859 Title: Edimax AC-1200 (rtl8812au) does not work on boot To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/rtl8812au/+bug/1509859/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs
