Hope everything comes out fine sooner than later. KR On Mon, 4 Aug 2025 at 10:33, Madras Sivaraman <[email protected]> wrote:
> Thank you for this very useful information. > > On Mon, 4 Aug 2025 at 10:27 AM, Rajaram Krishnamurthy < > [email protected]> wrote: > >> Recent news in 2025 highlights advancements in artificial kidney >> research, with a focus on portability, bioartificial kidney prototypes, and >> potential clinical trials. Researchers are making strides in miniaturizing >> devices, exploring bioartificial kidney components, and even developing >> wearable options for continuous dialysis. >> >> 1. Portable Artificial Kidneys: >> >> SNU researchers have developed a portable artificial kidney using nano >> electrokinetic technology, enabling continuous regeneration of peritoneal >> dialysate, a key component in dialysis. >> >> This innovation aims to make kidney failure treatment more accessible and >> convenient for patients. >> >> The Artificial Kidney Innovation Lab is also focused on creating >> patient-friendly, portable devices. >> >> 2. Bioartificial Kidney Progress: >> >> The Kidney Project has successfully tested a prototype bioartificial >> kidney, combining a hemofilter and a bioreactor. >> >> This device aims to mimic the natural function of the kidney, with the >> bioreactor containing lab-grown kidney cells. >> >> The project has received funding and recognition, including a KidneyX >> award, for its work on improving dialysis, especially for at-home use. >> >> Researchers have successfully implanted a smartphone-sized prototype in >> animals and are working towards clinical trials. >> >> UCSF is also exploring the use of silicon fabrication technology to >> shrink the device further, aiming for a coffee cup-sized implantable >> device. >> >> 3. Clinical Trials and Future Directions: >> >> Pig-to-human kidney transplants are entering clinical trials, with >> initial procedures planned at Johns Hopkins. >> >> The goal is to expand xenotransplantation to more patients, pending >> successful results from these trials. >> >> Dr. Shuvo Roy also presented updates on the implantable bioartificial >> kidney at the European Society for Artificial Organs (ESAO) 2025 >> Conference. >> >> Researchers are working towards a commercially available artificial >> kidney by the end of the decade, though timelines may be affected by >> funding and technical challenges. >> >> 4. Novel Filtration Technologies: >> >> Researchers are exploring new membrane materials, like cellulose, which >> may offer superior filtering performance compared to existing materials. >> >> This could lead to improvements in both traditional dialysis and >> artificial kidney devices. >> >> 5. Wearable Artificial Kidney (WAK): >> >> The WAK is a miniaturized dialysis machine designed for continuous use, >> allowing patients to wear it 24/7. >> >> It has been clinically tested in Europe and the US, but is still >> considered experimental and not yet FDA-approved for public use. >> >> The WAK is part of the broader effort to develop more convenient and >> accessible kidney replacement therapies. >> >> BUT IN INDIA >> >> Yes, there are ongoing developments in artificial kidney technology, and >> while a fully functional, implantable artificial kidney is not yet >> available, there are promising advancements in both wearable and >> bioartificial kidneys. Here’s an overview of the current state of >> artificial kidney technology: >> >> 1. Wearable Artificial Kidneys >> >> Concept: Wearable artificial kidneys are devices designed to be worn >> outside the body and connected to the patient via tubing. They aim to >> provide continuous dialysis, which can be more convenient and less >> restrictive compared to traditional dialysis. >> >> Status: Several prototypes have been developed, such as the Wearable >> Artificial Kidney (WAK) and the Portable Artificial Kidney, which are in >> various stages of clinical trials. These devices offer the potential for >> more flexible treatment options and improved quality of life for patients >> with end-stage renal disease (ESRD). >> >> 2. Bioartificial Kidneys >> >> Concept: Bioartificial kidneys combine biological elements with synthetic >> materials to mimic the function of a natural kidney. These devices use >> living kidney cells to filter blood and remove waste products. >> >> Status: Research is ongoing in this area, with the development of devices >> like the Kidney Project’s bioartificial kidney, which aims to integrate >> kidney cells with a dialysis machine. This technology is still in the >> experimental phase but shows promise for future clinical use. >> >> 3. Implantable Artificial Kidneys >> >> Concept: An implantable artificial kidney would be a device that can be >> surgically implanted within the body to replace kidney function. This would >> ideally eliminate the need for external dialysis machines or frequent >> treatments. >> >> Status: As of now, implantable artificial kidneys are primarily in the >> research and development phase. Advances in bioengineering and materials >> science are working towards creating a viable and functional implantable >> device. >> >> 4. Current Technologies and Alternatives >> >> Dialysis: Traditional dialysis remains the primary treatment for patients >> with severe kidney dysfunction. It includes hemodialysis and peritoneal >> dialysis, which are effective but can be time-consuming and have lifestyle >> impacts. >> >> Kidney Transplant: Kidney transplantation is currently the most effective >> long-term solution for end-stage kidney disease, offering improved quality >> of life compared to dialysis. >> >> Challenges and Future Directions >> >> Biocompatibility: Ensuring that artificial kidneys are biocompatible and >> do not cause adverse reactions in the body is a significant challenge. >> >> Long-Term Functionality: Achieving long-term functionality and durability >> of these devices is crucial for their success. >> >> Regulation and Approval: New technologies must undergo rigorous testing >> and regulatory approval before they can be widely available for clinical >> use. >> >> Conclusion >> >> While a fully functional, implantable artificial kidney is not yet >> available, significant progress is being made in wearable and bioartificial >> kidneys. These advancements hold the potential to revolutionize the >> treatment of kidney failure by offering more convenient and effective >> options for patients. Ongoing research and development in this field >> continue to bring us closer to more practical and widely accessible >> solutions. >> >> May be phase 1 is around the corner in India. K RAJARAM IRS 4825 >> >> -- >> On Facebook, please join https://www.facebook.com/groups/keralaiyerstrust >> >> We are now on Telegram Mobile App also, please join >> >> Pattars/Kerala Iyers Discussions: https://t.me/PattarsGroup >> >> Kerala Iyers Trust Decisions only posts : https://t.me/KeralaIyersTrust >> >> Kerala Iyers Trust Group for Discussions: >> https://t.me/KeralaIyersTrustGroup >> --- >> You received this message because you are subscribed to the Google Groups >> "KeralaIyers" group. >> To unsubscribe from this group and stop receiving emails from it, send an >> email to [email protected]. >> To view this discussion visit >> https://groups.google.com/d/msgid/keralaiyers/CAL5XZoqiMJted_cvRJJbNO7Q-kGfTPTmjnDePVDRHrZstoSO-A%40mail.gmail.com >> <https://groups.google.com/d/msgid/keralaiyers/CAL5XZoqiMJted_cvRJJbNO7Q-kGfTPTmjnDePVDRHrZstoSO-A%40mail.gmail.com?utm_medium=email&utm_source=footer> >> . >> > -- > On Facebook, please join https://www.facebook.com/groups/keralaiyerstrust > > We are now on Telegram Mobile App also, please join > > Pattars/Kerala Iyers Discussions: https://t.me/PattarsGroup > > Kerala Iyers Trust Decisions only posts : https://t.me/KeralaIyersTrust > > Kerala Iyers Trust Group for Discussions: > https://t.me/KeralaIyersTrustGroup > --- > You received this message because you are subscribed to the Google Groups > "KeralaIyers" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > To view this discussion visit > https://groups.google.com/d/msgid/keralaiyers/CADLnUxjuj5U84-Sfkj4KyQ22WOJvCUuuyQTmnXRkFykM7do8jA%40mail.gmail.com > <https://groups.google.com/d/msgid/keralaiyers/CADLnUxjuj5U84-Sfkj4KyQ22WOJvCUuuyQTmnXRkFykM7do8jA%40mail.gmail.com?utm_medium=email&utm_source=footer> > . > -- You received this message because you are subscribed to the Google Groups "Thatha_Patty" group. 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