Re: [R] A general question about targeted sequencing data analysis

2020-12-03 Thread Jeff Newmiller
My suggestion would be to ask this question in a forum devoted to that topic, such as the Bioconductor forum [1]. [1] https://www.bioconductor.org/help/support/ On December 3, 2020 11:25:24 AM PST, "Li, Aiguo (NIH/NCI) [E] via R-help" wrote: >Dear all, > >One of our PIs has a targeted sequenci

[R] A general question about targeted sequencing data analysis

2020-12-03 Thread Li, Aiguo (NIH/NCI) [E] via R-help
Dear all, One of our PIs has a targeted sequencing dataset generated a while ago. He is interested in finding out VAF of a group of genes. This is the first dataset of this types we have. I would be appreciative for any suggestions on pipelines for analyzing this type of data. Thanks Anna

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread Philip Rhoades
David, On 2019-03-20 12:38, David Winsemius wrote: On 3/19/19 12:49 PM, Jeff Newmiller wrote: Highly off topic. Try StackOverflow. As it stands it's off-topic for SO. (You would just be making more work for those of us who know the rules but need 4 close votes for migration.)  Better would b

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread David Winsemius
On 3/19/19 12:49 PM, Jeff Newmiller wrote: Highly off topic. Try StackOverflow. As it stands it's off-topic for SO. (You would just be making more work for those of us who know the rules but need 4 close votes for migration.)  Better would be immediately posting at CrossValidated.com (i.e

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread Jeff Newmiller
Highly off topic. Try StackOverflow. On March 19, 2019 10:42:24 AM PDT, Philip Rhoades wrote: >People, > >I have only a general statistics understanding and have never actually >used Bayes' Theorem for any real-world problem. My interest lies in >developing some statistical approach for addres

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread David Winsemius
Actually the list is not moderated in the usual sense of the word. If you subscribe, your posts are not moderated. Only your first posting after subscription would be moderated, but for the purpose of preventing persons with obvious spamming goals. And there are several different moderators. I

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread Marc Schwartz via R-help
> On Mar 19, 2019, at 2:06 PM, Evan Cooch wrote: > > Just curious -- if R-help is a moderated list (which in theory , it is -- my > posts have been 'modertated', to the degree that they aren't released to the > list until someone approves them), and if these 'statistics discussion' > quest

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread Evan Cooch
Just curious -- if R-help is a moderated list (which  in theory , it is -- my posts have been 'modertated', to the degree that they aren't released to the list until someone approves them), and if these 'statistics discussion' questions are inappropriate to the mission (as described), then...wh

Re: [R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread David Winsemius
Rhelp is not a forum for discussions of statistics. Instead it is for persons who have specific questions about the use of R. Please read the list info page where you started the subscription process. And do read the Posting Guide. Both these are linked at the bottom of this response. There

[R] A general question about using Bayes' Theorem for calculating the probability of The End of Human Technological Civilisation

2019-03-19 Thread Philip Rhoades
People, I have only a general statistics understanding and have never actually used Bayes' Theorem for any real-world problem. My interest lies in developing some statistical approach for addressing the subject above and it seems to me that BT is what I should be looking at? However, what I

Re: [R] A general question: Is language S a component part of R?

2012-11-06 Thread Suzen, Mehmet
On Tue, Nov 6, 2012 at 2:34 AM, Hadley Wickham wrote: > On Monday, November 5, 2012, Rolf Turner wrote: > >> On 06/11/12 09:40, Iurie Malai wrote: >> >>> So, R (as a language) can be viewed as an extended S language (S + some >>> improvements)? And the R environment includes this (extended) langua

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Hadley Wickham
On Monday, November 5, 2012, Rolf Turner wrote: > On 06/11/12 09:40, Iurie Malai wrote: > >> So, R (as a language) can be viewed as an extended S language (S + some >> improvements)? And the R environment includes this (extended) language + >> extensions? >> > > Are others getting as sick of this

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread David L Carlson
lto:r-help-bounces@r- > project.org] On Behalf Of R. Michael Weylandt > > Sent: Monday, November 05, 2012 3:48 PM > To: Iurie Malai > Cc: r-help@r-project.org > Subject: Re: [R] A general question: Is language S a component part of > R? > > > > On Nov 5, 2012, at

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread R. Michael Weylandt
On Nov 5, 2012, at 6:37 PM, Iurie Malai wrote: > Thanks all! > > At least for me, the manual text has a contradiction. If R is much like S, > in other words it is a "diverged" S, as Michael says, it can't include > itself as a component part. I'd think something like C/C++ -- the later includ

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Berend Hasselman
On 05-11-2012, at 22:04, Rolf Turner wrote: > On 06/11/12 09:40, Iurie Malai wrote: >> So, R (as a language) can be viewed as an extended S language (S + some >> improvements)? And the R environment includes this (extended) language + >> extensions? > > Are others getting as sick of this silly,

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Rolf Turner
On 06/11/12 09:40, Iurie Malai wrote: So, R (as a language) can be viewed as an extended S language (S + some improvements)? And the R environment includes this (extended) language + extensions? Are others getting as sick of this silly, pedantic and completely irrelevant pseudo-scholasticism as

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Iurie Malai
; language.) > > Bill Dunlap > Spotfire, TIBCO Software > wdunlap tibco.com > > > > -Original Message- > > From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] > On Behalf > > Of Iurie Malai > > Sent: Monday, November 05, 2012 11:38 AM >

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread William Dunlap
gt; To: Patrick Burns > Cc: r-help@r-project.org > Subject: Re: [R] A general question: Is language S a component part of R? > > After reading the 'Inferno-ish R' the first thing that comes to mind is > that R is very much like S, but it's still different (R is not S), so

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Iurie Malai
After reading the 'Inferno-ish R' the first thing that comes to mind is that R is very much like S, but it's still different (R is not S), so it can't contain the S as a programming language, as the manual says. Or I'm wrong? 2012/11/5 Patrick Burns > There is a bit of history in: > > http://ww

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Patrick Burns
There is a bit of history in: http://www.portfolioprobe.com/2012/05/31/inferno-ish-r/ Pat On 05/11/2012 17:09, R. Michael Weylandt wrote: On Mon, Nov 5, 2012 at 4:43 PM, Iurie Malai wrote: In the "Introduction and preliminaries" the "An Introduction to R" manual says about R: "... Among oth

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread Iurie Malai
Thanks all! At least for me, the manual text has a contradiction. If R is much like S, in other words it is a "diverged" S, as Michael says, it can't include itself as a component part. Regards, Iurie 2012/11/5 R. Michael Weylandt > On Mon, Nov 5, 2012 at 4:43 PM, Iurie Malai wrote: > > In t

Re: [R] A general question: Is language S a component part of R?

2012-11-05 Thread R. Michael Weylandt
On Mon, Nov 5, 2012 at 4:43 PM, Iurie Malai wrote: > In the "Introduction and preliminaries" the "An Introduction to R" manual > says about R: "... Among other things it has ... a well developed, simple > and effective programming language (Called 'S') ... ". Now I'm a little > confused. This mean

[R] A general question: Is language S a component part of R?

2012-11-05 Thread Iurie Malai
In the "Introduction and preliminaries" the "An Introduction to R" manual says about R: "... Among other things it has ... a well developed, simple and effective programming language (Called 'S') ... ". Now I'm a little confused. This means that language S is a component part of R? And S is not fre

Re: [R] a general question

2009-03-10 Thread culpritNr1
Hello Bogdan, Put in those terms, option b looks more defensible. It sounds like a test of two proportions, sometimes called z-test. The problem is that, for that test to be used, you must be sampling from large population. You know that under regular ChIP-seq sequencing we are lucky if we get 1

[R] a general question

2009-03-06 Thread Bogdan Tanasa
Hi everyone, Although this question is more related to ChIP and ChIP-seq, it could be probably anchored in a more general statistical context. The question is : what method is better to assess the significance of the change in a signal (the signal can be DNA binding, for instance) given the bac