Hi Frank,
Thank you for the correction, I don't work in clinical, so good you keep
me honest.
Nicholas
On Sun, 11 Jan 2009 09:21:23 -0600, "Frank E Harrell Jr"
said:
> Nicholas please note that FDA does not require type III sums of squares,
> LOCF, and the use of any particular software. It is j
Nicholas please note that FDA does not require type III sums of squares,
LOCF, and the use of any particular software. It is just the fact that
FDA does not disallow type III tests and LOCF that prevents pharma from
abandoning these terrible methods.
Frank
--
Frank E Harrell Jr Professor an
Hi all,
One relatively easy solution is to include R and all relevant versions
of packages used in (a) a reproduction archive and/or (b) packaged
inside a virtual machine. With storage space cheap and sources of both
R and packages available (and easy free crossplatform virtual machine
sol
Hi,
Unfortunately one of the the cornerstones of the validation paradigm
in the clinical world (as I understand it) is that
consistency/repeatability,
documentation (of the programs consistency and maintenance) and
adherence to regulatory
requirements take supremacy even ironically over correctness
Hi Nicholas,
You raise a very good point. As an R user (who develops a couple of
packages for our own local use), I sometimes find myself cringing in
anticipation of a new R (or BioConductor) release. In my perception
(which is almost certainly exaggerated, but that's why I emphasize that
it
Hi,
Kudos, nice exposure, but to make this more appropriate to R-devel I
would just
like to make a small comment about the point made by the SAS executive
about getting
on an airplane yada yada ...
1) It would seem to me that R has certification documents
2) anyone designing airplanes, analyzing c
It has been all over R-help, in several threads.
https://stat.ethz.ch/pipermail/r-help/2009-January/184119.html
https://stat.ethz.ch/pipermail/r-help/2009-January/184170.html
https://stat.ethz.ch/pipermail/r-help/2009-January/184209.html
https://stat.ethz.ch/pipermail/r-help/2009-January/184232.h
