Same thing here, karmic with 185.18.36 and I thought it was an issue
with alpha kernels- obviously not:

glxinfo 
name of display: :0.0
NVIDIA: could not open the device file /dev/nvidiactl (Permission denied).
display: :0  screen: 0
direct rendering: No (If you want to find out why, try setting 
LIBGL_DEBUG=verbose)


sudo glxinfo 
name of display: :0.0
display: :0  screen: 0
direct rendering: Yes

-- 
No Nvidia direct rendering unless root user
https://bugs.launchpad.net/bugs/370249
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