For me this is reproducible on 21.10, so this should be reopened. Using the popups (e.g. brush selection) seem to only lose control of mouse input. When mouse is unresponse, the keyboard is still responsive: pressing B opens the brush selection, pressing Shift shows the guide text at bottom toolbar, etc.
Sometimes activating controls using keyboard also brings back mouse control, but I did not find a reliable procedure for this. Starting mypaint from terminal displays sometimes but not always: (mypaint:19562): Gdk-WARNING **: 11:29:21.910: Tried to unmap the parent of a popup -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1947294 Title: MyPaint crashes/freezes after interacting with its interface To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/mypaint/+bug/1947294/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs