It turns out the MOK key installed previously was removed during a BIOS update. Upon the next kernel update from Ubuntu I was prompted to install the MOK key, after which OpenCL works even when kernel lockdown is enabled.
** Changed in: nvidia-graphics-drivers-440 (Ubuntu) Status: New => Invalid -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1887249 Title: OpenCL doesn't work when kernel lockdown enabled To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/nvidia-graphics-drivers-440/+bug/1887249/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs