I encountered the same issue and was able to solve it by adding
i8042.reset=1 to the kernel command line.  i8042.nomux was not necessary
for me.

The quirk was committed in
https://git.kernel.org/pub/scm/linux/kernel/git/torvalds/linux.git/commit/?id=2712c91a54a1058d55c284152b4d93c979b67be6
which is included in Linux 5.7.  It has also been merged into stable for
the upcoming v5.6.16, v5.4.44, v4.19.126, v4.14.183, v4.9.226, and
v4.4.226.

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https://bugs.launchpad.net/bugs/1210748

Title:
  On Lenovo Thinkpad Twist internal mouse does not work after turning on
  machine, only works after reboot

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