Today I installed Ubuntu Studio 18.10 64bit, after install I updated 
4.18.0-18-lowlatency and now instead of what I observed in 4.15 kernels, see 
that IRQ16 nobody cares does not occur and my mouse is OK.  A780gm-a 
motherboard , SB700. 
Happier that I have progress but note I have IRQ18 nobody cares event and an 
IRQ18 disabled occurring.  Moving my mouse to the front panel exhibits same 
laggy behavior. 
$ cat /proc/interrupts
           CPU0       CPU1       CPU2       CPU3      
  0:        116          0          0          0   IO-APIC   2-edge      timer
  1:          0          0        775          0   IO-APIC   1-edge      i8042
  8:          0          0          0          1   IO-APIC   8-edge      rtc0
  9:          0          0          0          0   IO-APIC   9-fasteoi   acpi
 14:          0          0          0          0   IO-APIC  14-edge      
pata_atiixp
 15:          0          0       1476          0   IO-APIC  15-edge      
pata_atiixp
 16:        571          0        107          0   IO-APIC  16-fasteoi   
ohci_hcd:usb3, ohci_hcd:usb4, snd_hda_intel:card0
 17:          0          0          0          0   IO-APIC  17-fasteoi   
ehci_hcd:usb1
 18:          0      51217          0          0   IO-APIC  18-fasteoi   
ohci_hcd:usb5, ohci_hcd:usb6, ohci_hcd:usb7, radeon
 19:         59          0          0         32   IO-APIC  19-fasteoi   
ehci_hcd:usb2, snd_hda_intel:card1
 22:       9134      36093          0          0   IO-APIC  22-fasteoi   
ahci[0000:00:11.0]
 24:          0          0          0      17924   PCI-MSI 1048576-edge      
enp2s0

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https://bugs.launchpad.net/bugs/1787743

Title:
  Slow USB mouse input on linux-lowlatency

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