FWIW With a Dell XPS 9360 and Kubuntu 17.10, same issue on the latest
kernel and many previous:

uname -a
Linux mulhollandd-XPS-13-9360 4.16.2-041602-generic #201804121130 SMP Thu Apr 
12 11:32:17 UTC 2018 x86_64 x86_64 x86_64 GNU/Linux

lsb
_release -a
No LSB modules are available.
Distributor ID: Ubuntu
Description:    Ubuntu 17.10
Release:        17.10
Codename:       artful

I will test the solution mentioned by @s-breedveld of applying:
"pci=nomsi iommu=soft" and report if this helps.

In my case this is a bluetooth mouse which disappears after suspend.

A dmesg output indicates:

[ 3380.759427] xhci_hcd 0000:00:14.0: xHC is not running.
[ 3380.774604] xhci_hcd 0000:00:14.0: xHCI host controller not responding, 
assume dead
[ 3380.774627] xhci_hcd 0000:00:14.0: HC died; cleaning up
[ 3380.775306] usb 2-1: USB disconnect, device number 2
[ 3381.059095] usb 1-1: USB disconnect, device number 2
[ 3381.059098] usb 1-1.2: USB disconnect, device number 4
[ 3381.059408] usb 1-3: USB disconnect, device number 3
[ 3381.059735] usb 1-5: USB disconnect, device number 5

A power-down is usually required to fix this, a reboot does bring the
device back to life.

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https://bugs.launchpad.net/bugs/1413440

Title:
  USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while
  waiting for setup device command)

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