I am having the same problem, but only after resume from suspend or
hibernate. I first thought it was a bluetooth problem, as my bluetooth
mouse stops working after a minute or so after resume. However, both the
bluetooth adapter is gone (bluetoothctl says "No Default controller"),
but also ordinary USB mice will not work.

It seems that HCI dies, and the kernel decides to remove everything else
as well. Touchpad works however.

I am running 18.04 alpha with 4.16rc3 (4.16.0-041600rc3-generic)
mainline kernel. Hardware: Lenovo Thinkpad E580.


Full syslog output. BTW: "MX Anywhere 2" is a BT mouse, not a keyboard. Not 
sure why it is registered as such.

Feb 28 14:18:00 miCycle bluetoothd[1040]: Unable to register org.bluez.Battery1 
interface for /org/bluez/hci0/dev_E8_02_AE_59_01_F8
Feb 28 14:18:01 miCycle kernel: [13423.017919] input: MX Anywhere 2 as 
/devices/virtual/misc/uhid/0005:046D:B018.0002/input/input19
Feb 28 14:18:01 miCycle kernel: [13423.018374] hid-generic 0005:046D:B018.0002: 
input,hidraw0: BLUETOOTH HID v0.09 Keyboard [MX Anywhere 2] on A0:D3:7A:E0:62:A2
Feb 28 14:18:01 miCycle upowerd[1731]: unhandled action 'bind' on 
/sys/devices/virtual/misc/uhid/0005:046D:B018.0002
Feb 28 14:18:15 miCycle blueman-mechanism: Exiting
Feb 28 14:18:42 miCycle kernel: [13464.682662] xhci_hcd 0000:00:14.0: xHC is 
not running.
Feb 28 14:18:42 miCycle kernel: [13464.724396] xhci_hcd 0000:00:14.0: xHCI host 
controller not responding, assume dead
Feb 28 14:18:42 miCycle kernel: [13464.724414] xhci_hcd 0000:00:14.0: HC died; 
cleaning up
Feb 28 14:18:42 miCycle kernel: [13464.746152] usb 1-5: USB disconnect, device 
number 4
Feb 28 14:18:42 miCycle kernel: [13464.801790] usb 1-6: USB disconnect, device 
number 3
Feb 28 14:18:42 miCycle systemd[1]: bluetooth.target: Unit not needed anymore. 
Stopping.
Feb 28 14:18:42 miCycle systemd[1]: Stopped target Bluetooth.
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.1
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.0
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.1
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.0
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-5
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/pci0000:00/0000:00:14.0/usb1/1-6
Feb 28 14:18:42 miCycle acpid: input device has been disconnected, fd 19
Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 
path=/MediaEndpoint/A2DPSource
Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 
path=/MediaEndpoint/A2DPSink
Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on 
/sys/devices/virtual/misc/uhid/0005:046D:B018.0002
Feb 28 14:18:42 miCycle NetworkManager[879]: <info>  [1519823922.9176] bluez5: 
NAP: removed interface A0:D3:7A:E0:62:A2

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https://bugs.launchpad.net/bugs/1413440

Title:
  USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while
  waiting for setup device command)

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