I am having the same problem, but only after resume from suspend or hibernate. I first thought it was a bluetooth problem, as my bluetooth mouse stops working after a minute or so after resume. However, both the bluetooth adapter is gone (bluetoothctl says "No Default controller"), but also ordinary USB mice will not work.
It seems that HCI dies, and the kernel decides to remove everything else as well. Touchpad works however. I am running 18.04 alpha with 4.16rc3 (4.16.0-041600rc3-generic) mainline kernel. Hardware: Lenovo Thinkpad E580. Full syslog output. BTW: "MX Anywhere 2" is a BT mouse, not a keyboard. Not sure why it is registered as such. Feb 28 14:18:00 miCycle bluetoothd[1040]: Unable to register org.bluez.Battery1 interface for /org/bluez/hci0/dev_E8_02_AE_59_01_F8 Feb 28 14:18:01 miCycle kernel: [13423.017919] input: MX Anywhere 2 as /devices/virtual/misc/uhid/0005:046D:B018.0002/input/input19 Feb 28 14:18:01 miCycle kernel: [13423.018374] hid-generic 0005:046D:B018.0002: input,hidraw0: BLUETOOTH HID v0.09 Keyboard [MX Anywhere 2] on A0:D3:7A:E0:62:A2 Feb 28 14:18:01 miCycle upowerd[1731]: unhandled action 'bind' on /sys/devices/virtual/misc/uhid/0005:046D:B018.0002 Feb 28 14:18:15 miCycle blueman-mechanism: Exiting Feb 28 14:18:42 miCycle kernel: [13464.682662] xhci_hcd 0000:00:14.0: xHC is not running. Feb 28 14:18:42 miCycle kernel: [13464.724396] xhci_hcd 0000:00:14.0: xHCI host controller not responding, assume dead Feb 28 14:18:42 miCycle kernel: [13464.724414] xhci_hcd 0000:00:14.0: HC died; cleaning up Feb 28 14:18:42 miCycle kernel: [13464.746152] usb 1-5: USB disconnect, device number 4 Feb 28 14:18:42 miCycle kernel: [13464.801790] usb 1-6: USB disconnect, device number 3 Feb 28 14:18:42 miCycle systemd[1]: bluetooth.target: Unit not needed anymore. Stopping. Feb 28 14:18:42 miCycle systemd[1]: Stopped target Bluetooth. Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.1 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.0 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.1 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.0 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6 Feb 28 14:18:42 miCycle acpid: input device has been disconnected, fd 19 Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 path=/MediaEndpoint/A2DPSource Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 path=/MediaEndpoint/A2DPSink Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/virtual/misc/uhid/0005:046D:B018.0002 Feb 28 14:18:42 miCycle NetworkManager[879]: <info> [1519823922.9176] bluez5: NAP: removed interface A0:D3:7A:E0:62:A2 -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1413440 Title: USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while waiting for setup device command) To manage notifications about this bug go to: https://bugs.launchpad.net/system76/+bug/1413440/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs