have you tried the command
pasuspender -- winecfg
?
You can start a program by issuing
pasuspender -- wine .wine/drive_c/Programmi/Macromedia/Flash\ 8/Flash.exe 
It suspends pulseaudio for a while and lets you use wine without the hassles it 
brings.

-- 
Wine randomly cannot initialize sound
https://bugs.launchpad.net/bugs/502375
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