Sorry - my mistake - try:

infile = open("filex")
match_zips = open("zippys")
result = [line for line in infile if line in match_zips]
print result
When I apply the readlines to the original file, It is taking a lot longer to process and the outfile still remains blank. Any suggestions?

#!/usr/bin/env python
# Find records that match zipcodes in zips.txt

import os
import sys

def main():
    infile = open("/Users/tgw/NM_2010/NM_APR.txt", "r")
    outfile = open("zip_match_apr_2010.txt", "w")
    zips = open("zips.txt", "r")
    match_zips = zips.readlines()
    lines = [ line for line in infile if line[149:154] in match_zips ]

    outfile.write(''.join(lines))
#    print line[149:154]
    print lines
    infile.close()
    outfile.close()
main()


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