I've never used Zope so I can't speak to its strengths or weaknesses.
But I can say that Django is quite natural if you already know Python.
It certainly is modular, with a ton of apps that you can plug in to
gain added functionality. And there's also a project called Pinax that
provides layers of CMS-type functionality (e.g. authentication,
blogging, wiki, etc.) that can save you from reinventing the wheel.

Here are a few places to explore:

http://djangoplugables.com/
http://pinaxproject.com/

Search Google Code for django

HTH,
Serdar
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