>> can I set "safe_mode = On" in "/etc/httpd/php.ini" without problems for
>> "squirrelmail"?
>
> Depends entirely upon related settings in php.ini as well as what
> plugins you are using, etc.  Basic SM functionalities should be unaffected
> for the most part, but you may have to fiddle with your attachments and
> maybe data directories.

Also, you might want to configure your web server to handle PHP settings
per site/directory/file and not globally. Some PHP applications conflict
in their dependencies (generally speaking, not necessarily SquirrelMail).

Sincerely,
Fredrik

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