Bug#1022042: linux-image-amd64: linux-image-5.10.0-19-amd64 fails to boot on machines with AMD integrated graphics
Can confirm this issue with a AMD Ryzen 3 2200G Processor with Vega 8 Graphics on a AsRock DeskMini A300.
Bug#750630: Bug#751385: newer python interfers with matplotlib
the workaround maks suggested works well, but you have to adjust all your scripts. If you want a global solution you can adjust your matplotlibrc (/etc/matplotlibrc or ~/.config/matplotlib/matplotlibrc) with backend : GTK or other backends like GTK3Cairo (which i'm using now). A sample conf