Dear R-Helpers Has anyone written a script for the dose proportionality assessement using the power model and the confidence interval criteria as described in
- Gough at al. Assessment of dose proportionality: report from the statisticians in the pharmaceutical industry in Drug Information Journal,1995, 29:1039-1048 and/or - Smith et al. Confidence interval criteria for assessment of dose proportionality in Pharmaceutical Research, 2000, 20:1278-1283 As an aside, and before tweaking the source of function NCAanalyze in the bear package, I wonder if anyone has a function for doing non compartimental PK analysis by subject on a dataframe with subject, time and concentration variates. Thanks in advance for sharing and helping me not re-invent the wheel (which might be square given my R skills). Best wishes, Jean-Louis Jean-Louis Abitbol, MD Chief Medical Officer Trophos SA, Parc scientifique de Luminy, Case 931 Luminy Biotech Entreprises 13288 Marseille Cedex 9 France Email: [EMAIL PROTECTED] ---- Backup Email: [EMAIL PROTECTED] Cellular: (33) (0)6 24 47 59 34 Direct Line: (33) (0)4 91 82 82 73-Switchboard: (33) (0)4 91 82 82 82 Fax: (33) (0)4 91 82 82 89 ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
