Dear R users,

is there a way, I mean a package, to perform a competing risk model which can 
handle time dependent covariates ?

my main covariate (additional treatment to patients) appears not to follow the 
proportional hazards assumption, its effect being observed after one year of 
treatment but not before (this is expected / makes sense on a clinical point of 
view). SO I was planning to use a time dependent Cox model with 2 time 
intervals for patients < > 1 year etc...

However, a large number of patients dies from treatment related complications 
of unrelated to the disease and the treatment (elderly patients) so to analyze 
the effect of my covariate of interest on disease free survival and relapse 
incidence, I d like to use a competing risk model such as the Gray CMPRSK.

My problem is that I cannot have multiple "lines" for the same patient with 
this package (for time dep covariates 2 or 3 lines with same Id /UPN). 
How can I manage this !!!???
Any help will be greatly appreciated 
Thanks
Yours sincerely


 


Philippe Guardiola


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