> On 23 Sep 2017, at 01:32, array chip via R-help <r-help@r-project.org> wrote: > > Hi, > > I am learning to use your gsDesign package! I have a question about Pocock > and OBF boundary. As far as Iunderstand, these 2 boundaries require equal > spacing between interim analyses(maybe this is not correct?). But I can still > use gsDesign to run an analysisbased on unequal spacing: > gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided > group sequential design with90 %power and 5 % Type I > Error.Spendingcomputations assume trial stops if a bound is crossed. > Sample Size AnalysisRatio* Z Nominal p Spend 1 0.796 > 1.82 0.0346 0.0346 2 1.061 1.82 0.0346 0.0154 Total > 0.0500 ++alpha spending:Pocockboundary.*Sample size ratio > compared to fixed design with no interim Can anyone share some light whether > the above analysis is stillvalid? Or for unequal spacing, I have to use > Lan-Demet’s error spendingfunction approximations? Thank you, > [[alternative HTML version deleted]] >
Your example code is a complete mess. Do NOT post in html. This is a plain text mailing list. Read the Posting Guide (https://www.r-project.org/posting-guide.html). Berend Hasselman] > ______________________________________________ > R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide http://www.R-project.org/posting-guide.html > and provide commented, minimal, self-contained, reproducible code. ______________________________________________ R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
