here is the solution to your question
test <- data.frame(C1=c('a,b,c,d'),C2=c('g,h,f'))
you should use gsub instead sub if you want it to be on all elements of
each column
tFun <- function(x) {gsub(",",";",x)}
newTest <- apply(test, 2, tFun )
Cheers,
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