On Oct 8, 2012, at 10:04 AM, "Kozielska-Reid MA, Magdalena" 
<m.a.kozielska-r...@pl.hanze.nl> wrote:

> 
> Dear all,
> 
> I have two questions:
> 
> 1. Does anyone know if nlmeODE package will work once odesolve is 
> discontinued? If i understand well nlmeODE depends on odesolve.
> 2. Can anyone suggest another package I could use to fit complex PKPD models 
> (described using differential equations) to data?
> 
> Thanks a lot!
> 
> Magdalena


You should probably contact the author of nlmeODE to see if he plans to update 
his package to perhaps use deSolve instead as well as other CRAN required 
updates (eg. a NAMESPACE). nlmeODE has not been updated in well over two years, 
which would logically raise some suspicions. Presumably nlmeODE will begin to 
more materially fail CRAN checks once odesolve is formally deprecated and may 
itself be deprecated/orphaned as a result. It already has NOTE entries in the 
CRAN checks for problems already found.

If you have not, you might want to look at the CRAN task view here:

  http://cran.r-project.org/web/views/Pharmacokinetics.html

which might provide some possible alternatives.

Regards,

Marc Schwartz

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