Hi Thomas, Thank you so much for your suggestion. I tried your code and it is working fine. Now when I change the values of Y in yobs I am getting so many warnings.
say, yobs <- data.frame( time = 0:7, Y = c(0.00, 3.40, 4.60 ,5.80, 5.80, 6.00, 6.00 ), Z = c(0.1, 0.11, 0.119, 0.128, 0.136, 0.145, 0.153, 0.16) ) So when i fit the model with the same code that you have written, i got the following warnings: DLSODA- Warning..Internal T (=R1) and H (=R2) are such that in the machine, T + H = T on the next step (H = step size). Solver will continue anyway. In above, R1 = 0.1484502806322D+01 R2 = 0.2264549048113D-16 and I have got so many such warnings. Can you explain me why this is happening?? and Secondly, I dont understand why i am getting parameters values in negatives after fitting?? Can you please help me out in this... :) Thanks Himanshu -- View this message in context: http://r.789695.n4.nabble.com/How-to-find-best-parameter-values-using-deSolve-n-optim-tp4506042p4535368.html Sent from the R help mailing list archive at Nabble.com. ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.