Hello,

Couple of clarifications: 
- A,B,C,D are factors and I am also interested in possible interactions but the 
model that comes out from aov R~A*B*C*D violates the model assumptions
- My 2^k is unbalanced i.e. missing data and an additional level I also include 
in one of the factors i.e. C
- I was referring in the OP to the 4-way interactions and not 2-way, I'm sorry 
for my confusion.
- I tried to create an aov model with less interactions this way but I get the 
following error:

model.aov <- aov(log(R)~A+B+I(A*B)+C+D,data=throughput)
Error in `contrasts<-`(`*tmp*`, value = "contr.treatment") : 
  contrasts can be applied only to factors with 2 or more levels
In addition: Warning message:
In Ops.factor(A, B) : * not meaningful for factors

Here I was trying to say: do a one-way anova except for the A and B factors for 
which I would like to get their 2-way interactions ...

Thanks in advance,
Best regards,
Giovanni

On Nov 21, 2011, at 12:04 PM, Giovanni Azua wrote:

> Hello,
> 
> I know there is plenty of people in this group who can give me a good answer 
> :)
> 
> I have a 2^k model where k=4 like this:
> Model 1) R~A*B*C*D
> 
> If I use the "*" in R among all elements it means to me to explore all 
> interactions and include them in the model i.e. I think this would be the so 
> called 2-way anova. However, if I do this, it leads to model violations i.e. 
> the homoscedasticity is violated, the normality assumption of the sample 
> errors i.e. residuals is violated etc. I tried correcting the issues using 
> different standard transformations: log, sqrt, Box-Cox forms etc but none 
> really improve the result. In this case even though the model assumptions do 
> not hold, some of the interactions are found to significatively influence the 
> response variable. But then shall I trust the results of this Model 1) given 
> that the assumptions do not hold?
> 
> Then I try this other model where I exclude the interactions (is this the 
> 1-way anova?):
> Model 2) R~A+B+C+D
> 
> In this one the model assumptions hold except the existence of some outliers 
> and a slightly heavy tail in the QQ-plot.
> 
> Given that the assumptions for Model 1) do not hold, I assume I should ignore 
> the results altogether for Model 1) or? or instead can I safely use the Sum 
> Sq. of Model 1) to get my table of percent of variations?
> 
> This to me was a bit counter-intuitive since I assumed that if there was 
> collinearity among factors (and there is e.g. I(A*B*C)) the Model 1) and I 
> included those interactions, my model would be more accurate ... ok this 
> turned into a brand new topic of model selection but I am mostly interested 
> in the question: if model is violated can I or must I not use the results 
> e.g. Sum Sqr for that model?
> 
> Can anyone advice please?
> 
> btw I have bought most books on R and statistical analysis. I have researched 
> them all and the ANOVA coverage is very shallow in most of them specially in 
> the R-sy ones, they just offer a slightly pimped up version of the R-help. 
> 
> I am also unofficially following a course on ANOVA from the university I am 
> registered in and most examples are too simplistic and either the assumptions 
> just hold easily or the assumptions don't hold and nothing happens.  
> 
> Thanks in advance,
> Best regards,
> Giovanni
> 


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