On Aug 16, 2011, at 6:36 AM, Jim Trabas wrote:

Dear R help gurus,


I have the following problem and I would be delighted if you could help me.

From a large (1500) cohort of patients we have been taking some measurements
(ECG measurements, but its not important). The measurements are ordinal in 4 grades (Grade I-IV, grade IV being the most severe form). Every patients has been measured several times (usually once per year). The follow-ups are different for each patient (ranging from days to several years), thus some patients have only 1 measurement and some have several. A patient can shift from Grade to Grade, that is a patient can be measured now as Grade I and later as Grade II and then at then next measurement he can return to Grade
I.

This should probably be followed up on the mixed models SIG list.

(Using Baron's RSiteSearch page.)

Search results with : repeated "proportional odds logistic"

http://finzi.psych.upenn.edu/R/library/repolr/html/00Index.html
http://finzi.psych.upenn.edu/R/Rhelp02/archive/99576.html

Search results with: repeated "ordered logit"

http://finzi.psych.upenn.edu/R/library/ordinal/doc/primer.pdf

That last one has citations to Agresti articles, which means it may have useful termininogy to be used in searching the very informative Thompson/Agresti compendium of R methods:

https://home.comcast.net/~lthompson221/Splusdiscrete2.pdf

The mixed-models SIG would seem to be a natural place to look and for that I use the advanced search panel fpr google to construct this search of its archives:

http://www.google.com/search?hl=en&lr=&q=repeated+logit+site%3Ahttps%3A%2F%2Fstat.ethz.ch%2Fpipermail%2Fr-sig-mixed-models

(I did trim some of the trailing bits that seemsed superfluous.)

--
David.

My data are in the following format

Patient ID, Time of Measurement, Grade

I would like to model the probability of being in each of the Grades (I-V) as a function of time. I guess i require a repeated measure cumulative logit
mixed model with random slope and intercept (for each patient).

Could anyone pin point me at any information that would help me accomplish
this in R? Packages? Books?

Information about categorical data analysis with R seems to be poor in the
Internet.

Thank you very much on advance
JT

--
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David Winsemius, MD
West Hartford, CT

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