Thank you for your answer.

According to the help, they are suggesting to use "layout" which I did.

However, font size is still reduced by the same factor.

Here's my code:

pdf(file="Fig5.pdf", width = 4.86, height = 6.29, family ='Times')
nf = layout(matrix(c(1:4), 2, 2, byrow = TRUE))
par(ps = 22)
hist( rnorm(100) ) 
hist( rnorm(100) ) 
hist( rnorm(100) ) 
hist( rnorm(100) ) 
dev.off()




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