On Thu, Aug 4, 2011 at 9:35 PM, Marc Schwartz <marc_schwa...@me.com> wrote:
>> Suppose that you are trying to create a binary logistic model by
>> trying different combinations of predictors. Has R got an automatic
>> way of doing this, i.e., is there some way of automatically generating
>> different tentative models and checking their corresponding AIC value?
>> If so, could you please direct me to an example?
>
> Hi Paul,
>
> If it were not for JSS going on at the moment, you would likely get a reply 
> from Frank Harrell telling you why using this approach is not a good idea. 
> This is tantamount to using a stepwise approach with variables going in and 
> out of the model, based upon either AIC or perhaps Wald p values.
>
> If you search the R list archives using rseek.org with keywords such as 
> "stepwise regression Harrell", you will see a plethora of discussions on this 
> over the years.
>
> You might want to obtain a copy of Frank's book Regression Modeling 
> Strategies along with Ewout Steyerberg's book Clinical Prediction Models, 
> which cover this topic and offer alternative solutions to model development. 
> These generally include the pre-specification of full models, considering how 
> many covariate degrees of freedom you can reasonably include in the model and 
> applying shrinkage/penalization.
>
> If you need to engage in data reduction, you might want to consider using the 
> LASSO, as implemented in the glmnet package on CRAN. More information on this 
> method is available at: http://www-stat.stanford.edu/~tibs/lasso.html. An 
> alternative might be backward elimination, which Frank does touch on and 
> covers in:
>
>  http://biostat.mc.vanderbilt.edu/wiki/pub/Main/RmS/rms.pdf
>
> which is a supplement to his course.
>
> Automated creation of models ignores the expertise of both the statistician 
> and subject matter experts, to the detriment of inference.

Thanks, Marc, for your very useful reply.

Paul

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