On Nov 8, 2010, at 11:16 AM, Mitchell Maltenfort wrote:

Not with R,

Really?

require(sos)
findFn("power exact test")
found 54 matches;  retrieving 3 pages
2 3

These look on point:
http://finzi.psych.upenn.edu/R/library/statmod/html/power.html

http://finzi.psych.upenn.edu/R/library/binom/html/cloglog.sample.size.html


Would also think that methods based on a poisson model of rare events could be informative:

http://finzi.psych.upenn.edu/R/library/asypow/html/asypow.n.html

--
David.

but look for G*Power3, a free tool for power calc,
includes FIsher's test.

http://www.psycho.uni-duesseldorf.de/abteilungen/aap/gpower3

On Mon, Nov 8, 2010 at 10:52 AM, Giulio Di Giovanni
<perimessagg...@hotmail.com> wrote:


Hi,
I'm try to compute the minimum sample size needed to have at least an 80% of power, with alpha=0.05. The problem is that empirical proportions are really small: 0.00154 in one case and 0.00234. These are the estimated failure proportion of two medical treatments. Thomas and Conlon (1992) suggested Fisher's exact test and proposed a computational method, which according to their table gives a sample size of roughly 20000. Unfortunately I cannot find any software applying their method. -Does anyone know how to estimate sample size on Fisher's exact test by using R? -Even better, does anybody know other, maybe optimal, methods for such a situation (small p1 and p2) and the corresponding R software?

Thanks in advance,
Giulio




David Winsemius, MD
West Hartford, CT

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