This summaryBy worked wonders! Thanks a lot djmuseR, I own you a beer!
> library(doBy)
> summaryBy(C ~ A + B, data = DF0, FUN = sum)
A B C.sum
1 52 1 124
2 52 59 38
3 52 97 75
4 57 1 64
5 57 6 26
6 57 114 12
7 89 1 192
8 89 6 20
9 89 29 137
10 89 52 13
11 89 57 10
12 89 97 23
--
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