Thanks Francois,
It worked as expected.
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source_data = open("source_data.bin", 'rb').read()
search_data = open("search_data.bin", 'rb').read()
replace_data = open("replace_data.bin", 'rb').read()
outFile = open("mod.bin", 'wb')
file_offset = source_data.find(search_data)
print "file_offset:", file_offset
outData = source_data.replace(search_data, replace_data)
outFile.write(outData)
outFile.close
print ""
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