Sounds like this was accidentally CC'ed to python-dev. On Sat, Apr 27, 2013 at 10:23 AM, 阮铮 <rz1...@foxmail.com> wrote: > Hi Eric and Peter, > > I'm preparing the proposal for the codon alignment project. Two things I may > want to hear your advice. > > 1) In the biopython wiki page, you mentioned "model selection" in the > Approach & Goals. I'm not sure if there are any advantages to use codon > alignment for model selection. Could you give me some references? Another > thing is that model selection involves estimation of tree topology as well > as branch lengthes and parameters across many substitution models. Will it > be too computationally intensive for a python implementation? > > 2) You also mentioned the "validation (testing for frame shift)". Is there a > test for frame shift? Or I can simply detect it by comparing amino acid > sequences and nucleotide sequences. > > Best, > Zheng Ruan > > _______________________________________________ > Python-Dev mailing list > Python-Dev@python.org > http://mail.python.org/mailman/listinfo/python-dev > Unsubscribe: > http://mail.python.org/mailman/options/python-dev/guido%40python.org >
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