I've been looking over a few perl 5.10.1 taint mode problems; the checks are stricter than they used to be causing errors in some software.
It would be good if some people who have been holding off updating for the past couple of months and are using earlier versions of perl (5.8.xx or 5.10.0) could update and check things are ok. One area you are particularly likely to run into problems is with Perl servers, especially those that drop privs themselves (though mod_perl uses should also check things out, and of course there might be others). These typically manifest as errors like 'Insecure dependency in [...] while running with -T switch'.