Baoyuantop commented on issue #12282:
URL: https://github.com/apache/apisix/issues/12282#issuecomment-2944640550

   As you can see from the logs:
   - `connect() failed (111: Connection refused)` error, indicating that APISIX 
was unable to connect to the backend service.
   - `upstream prematurely closed connection` error, indicating that the 
backend service closed the connection abnormally while processing the request.
   
   My personal deduction from this information:
   1. The backend gRPC service may be intermittently unavailable, are there any 
checks?
   2. Recommended to turn on [health 
check](https://apisix.apache.org/docs/apisix/tutorials/health-check/) for 
upstream to detect and remove unhealthy nodes in a timely manner.


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