Some DNS requests on my machine take 5 seconds when a specific network interface is used.
My big apologies for the confusion. I have found the reason. There was a scripted tc qdisc add dev enp3s0 root netem loss 5% in effect that I wasn't aware of while investigating. This dropped 5% of the packets, and also explains why it was on that interface only. Well, at least I know very well now at which level `tc` operates. My bad, and sorry for the noise.