Your kernel log shows it is having trouble with the mouse. This might be a fault with the mouse or the USB port. It might also be a kernel bug, but that's less likely...
[ 551.252894] usb 1-6: reset low-speed USB device number 3 using xhci_hcd [ 551.520701] usb 1-6: device descriptor read/64, error -71 [ 556.957250] usb 1-6: reset low-speed USB device number 3 using xhci_hcd [ 557.733478] usb 1-6: USB disconnect, device number 3 [ 558.061164] usb 1-6: new low-speed USB device number 4 using xhci_hcd [ 558.212826] usb 1-6: New USB device found, idVendor=046d, idProduct=c05a [ 558.212832] usb 1-6: New USB device strings: Mfr=1, Product=2, SerialNumber=0 [ 558.212837] usb 1-6: Product: USB Optical Mouse [ 558.212841] usb 1-6: Manufacturer: Logitech [ 558.215745] input: Logitech USB Optical Mouse as /devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.0/0003:046D:C05A.0005/input/input15 [ 558.216101] hid-generic 0003:046D:C05A.0005: input,hidraw3: USB HID v1.11 Mouse [Logitech USB Optical Mouse] on usb-0000:00:14.0-6/input0 [ 687.645465] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 777.148862] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 777.417072] usb 1-6: Device not responding to setup address. [ 777.625107] usb 1-6: Device not responding to setup address. [ 777.832620] usb 1-6: device not accepting address 4, error -71 [ 778.100621] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 1095.999728] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 1096.267472] usb 1-6: device descriptor read/64, error -71 [ 1096.643504] usb 1-6: device descriptor read/64, error -71 [ 1097.019526] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 1097.287539] usb 1-6: device descriptor read/64, error -71 [ 1097.663495] usb 1-6: device descriptor read/64, error -71 [ 1098.039490] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 1098.039923] usb 1-6: Device not responding to setup address. [ 1098.247947] usb 1-6: Device not responding to setup address. [ 1098.455509] usb 1-6: device not accepting address 4, error -71 [ 1098.723506] usb 1-6: reset low-speed USB device number 4 using xhci_hcd [ 1098.723945] usb 1-6: Device not responding to setup address. [ 1098.931938] usb 1-6: Device not responding to setup address. [ 1099.139470] usb 1-6: device not accepting address 4, error -71 [ 1099.139617] usb 1-6: USB disconnect, device number 4 [ 1099.327521] usb 1-6: new low-speed USB device number 5 using xhci_hcd [ 1099.455500] usb 1-6: device descriptor read/64, error -71 [ 1099.691465] usb 1-6: device descriptor read/64, error -71 [ 1099.927528] usb 1-6: new low-speed USB device number 6 using xhci_hcd [ 1100.055542] usb 1-6: device descriptor read/64, error -71 [ 1100.291539] usb 1-6: device descriptor read/64, error -71 [ 1100.399599] usb usb1-port6: attempt power cycle [ 1101.055512] usb 1-6: new low-speed USB device number 7 using xhci_hcd [ 1101.055908] usb 1-6: Device not responding to setup address. [ 1101.263962] usb 1-6: Device not responding to setup address. [ 1101.471513] usb 1-6: device not accepting address 7, error -71 [ 1101.599512] usb 1-6: new low-speed USB device number 8 using xhci_hcd [ 1101.599924] usb 1-6: Device not responding to setup address. [ 1101.807962] usb 1-6: Device not responding to setup address. [ 1102.015541] usb 1-6: device not accepting address 8, error -71 [ 1102.015632] usb usb1-port6: unable to enumerate USB device [ 1143.931796] usb 1-6: new low-speed USB device number 9 using xhci_hcd [ 1144.083477] usb 1-6: New USB device found, idVendor=046d, idProduct=c05a [ 1144.083483] usb 1-6: New USB device strings: Mfr=1, Product=2, SerialNumber=0 [ 1144.083487] usb 1-6: Product: USB Optical Mouse ** Package changed: xorg (Ubuntu) => linux (Ubuntu) -- You received this bug notification because you are a member of Kernel Packages, which is subscribed to linux in Ubuntu. https://bugs.launchpad.net/bugs/1834578 Title: Mouse stop working Status in linux package in Ubuntu: Confirmed Bug description: USB mouse stop working randomly ProblemType: Bug DistroRelease: Ubuntu 18.04 Package: xorg 1:7.7+19ubuntu7.1 ProcVersionSignature: Ubuntu 4.15.0-53.57-generic 4.15.18 Uname: Linux 4.15.0-53-generic x86_64 NonfreeKernelModules: nvidia_modeset nvidia .proc.driver.nvidia.gpus.0000.01.00.0: Error: [Errno 21] Is a directory: '/proc/driver/nvidia/gpus/0000:01:00.0' .proc.driver.nvidia.registry: Binary: "" .proc.driver.nvidia.version: NVRM version: NVIDIA UNIX x86_64 Kernel Module 390.116 Sun Jan 27 07:21:36 PST 2019 GCC version: gcc version 7.4.0 (Ubuntu 7.4.0-1ubuntu1~18.04.1) ApportVersion: 2.20.9-0ubuntu7.6 Architecture: amd64 BootLog: Error: [Errno 13] Permission denied: '/var/log/boot.log' CompositorRunning: None CurrentDesktop: ubuntu:GNOME Date: Fri Jun 28 10:24:54 2019 DistUpgraded: Fresh install DistroCodename: bionic DistroVariant: ubuntu DkmsStatus: nvidia, 390.116, 4.15.0-52-generic, x86_64: installed nvidia, 390.116, 4.15.0-53-generic, x86_64: installed virtualbox, 5.2.18, 4.15.0-52-generic, x86_64: installed virtualbox, 5.2.18, 4.15.0-53-generic, x86_64: installed GraphicsCard: NVIDIA Corporation GP107 [GeForce GTX 1050 Ti] [10de:1c82] (rev a1) (prog-if 00 [VGA controller]) Subsystem: ASUSTeK Computer Inc. GP107 [GeForce GTX 1050 Ti] [1043:85d3] InstallationDate: Installed on 2018-09-21 (280 days ago) InstallationMedia: Ubuntu 18.04.1 LTS "Bionic Beaver" - Release amd64 (20180725) Lsusb: Bus 002 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub Bus 001 Device 009: ID 046d:c05a Logitech, Inc. M90/M100 Optical Mouse Bus 001 Device 002: ID 0518:5111 EzKEY Corp. Bus 001 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub MachineType: System manufacturer System Product Name ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-4.15.0-53-generic root=UUID=8e5738ba-3515-4603-abfb-a837482ef7ba ro quiet splash vt.handoff=1 SourcePackage: xorg UpgradeStatus: No upgrade log present (probably fresh install) dmi.bios.date: 07/07/2017 dmi.bios.vendor: American Megatrends Inc. dmi.bios.version: 0809 dmi.board.asset.tag: Default string dmi.board.name: PRIME B250M-K dmi.board.vendor: ASUSTeK COMPUTER INC. dmi.board.version: Rev X.0x dmi.chassis.asset.tag: Default string dmi.chassis.type: 3 dmi.chassis.vendor: Default string dmi.chassis.version: Default string dmi.modalias: dmi:bvnAmericanMegatrendsInc.:bvr0809:bd07/07/2017:svnSystemmanufacturer:pnSystemProductName:pvrSystemVersion:rvnASUSTeKCOMPUTERINC.:rnPRIMEB250M-K:rvrRevX.0x:cvnDefaultstring:ct3:cvrDefaultstring: dmi.product.family: To be filled by O.E.M. dmi.product.name: System Product Name dmi.product.version: System Version dmi.sys.vendor: System manufacturer version.compiz: compiz N/A version.libdrm2: libdrm2 2.4.97-1ubuntu1~18.04.1 version.libgl1-mesa-dri: libgl1-mesa-dri 19.0.2-1ubuntu1.1~18.04.1 version.libgl1-mesa-glx: libgl1-mesa-glx 19.0.2-1ubuntu1.1~18.04.1 version.nvidia-graphics-drivers: nvidia-graphics-drivers-* N/A version.xserver-xorg-core: xserver-xorg-core 2:1.19.6-1ubuntu4.3 version.xserver-xorg-input-evdev: xserver-xorg-input-evdev N/A version.xserver-xorg-video-ati: xserver-xorg-video-ati 1:18.0.1-1 version.xserver-xorg-video-intel: xserver-xorg-video-intel 2:2.99.917+git20171229-1 version.xserver-xorg-video-nouveau: xserver-xorg-video-nouveau 1:1.0.15-2 To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1834578/+subscriptions -- Mailing list: https://launchpad.net/~kernel-packages Post to : kernel-packages@lists.launchpad.net Unsubscribe : https://launchpad.net/~kernel-packages More help : https://help.launchpad.net/ListHelp