Thanks again for your help.  I may have looked at this in a different way to 
what you suggested, but I sent a couple of test messages from outside through 
our ISP’s mail gateway.  I checked on their server using a webmail interface, 
and couldn’t see anything untoward in the message headers.  We have a 
multi-drop POP3 mailbox on the ISP, and our server uses a program called 
Fetchmail to download all the messages, handing each downloaded message to a 
program called Trestlemail which examines the header before dropping it off to 
the correct recipient.  As I said, I sent a couple of messages through, one 
when the intended recipient had an Out Of Office message set, and one when the 
Out Of Office message was off.  I then looked at the complete messages in the 
Cyrus store, and noticed that both messages had two lines which read:
 
Return-Path:   r...@server.domain
 
I’m not sure if I’m barking up the wrong tree, but I then looked at the Postfix 
master.cf file, and saw the following lines:
 
cyrus   unix      -     n     n     -     -     pipe
  flags=R user=cyrus argv=/usr/cyrus/bin/deliver -e -f $sender -m ${extension} 
${user}
 
I read somewhere that the second line might need a ‘-r ${sender}’ parameter 
added.  Am I onto something here?
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