https://gcc.gnu.org/bugzilla/show_bug.cgi?id=102139
--- Comment #5 from Andrew Pinski <pinskia at gcc dot gnu.org> --- Here is a testcase which fails with -O3 -fno-tree-loop-ivcanon -fno-tree-forwprop -mgeneral-regs-only -fno-tree-loop-distribute-patterns -fno-vect-cost-model -mstrict-align -fno-tree-fre -fno-tree-loop-vectorize : typedef decltype(sizeof(0)) size_t; typedef unsigned short uint16_t; typedef unsigned uint32_t; void zero_two_uint16(uint16_t* ptr) { ptr[0] = 0; ptr[1] = 0; } #define vector __attribute__((vector_size(sizeof(uint16_t)*4))) void f(uint16_t *a) { vector uint16_t *b = (vector uint16_t *)a; *b = (vector uint16_t){}; } void g(uint16_t *a) { size_t t = (size_t)a; if ((t & 0x7)==0) { for(size_t i = 0;i < 2;i++) f((a + i*4)); } else { for(size_t i = 0;i < 2;i++) zero_two_uint16((a + i*2)); } } Which shows the cleanups don't make a difference and some other patch is causing it but it was still working in GCC 10.