https://gcc.gnu.org/bugzilla/show_bug.cgi?id=69899
--- Comment #5 from Arseny Solokha <asolokha at gmx dot com> --- I believe practically all gcc branches, the current gcc-11.0.1-alpha20210314 snapshot (g:c2d7c39fcb8a3cb67600cdb6fde49ecb0e951589) included, demonstrate the same issue on gcc/testsuite/gcc.target/s390/vector/long-double-asm-commutative.c w/ -O1 -ffinite-math-only: % x86_64-unknown-linux-gnu-gcc-11.0.1 -O1 -ffinite-math-only -c gcc/testsuite/gcc.target/s390/vector/long-double-asm-commutative.c gcc/testsuite/gcc.target/s390/vector/long-double-asm-commutative.c: In function 'main': gcc/testsuite/gcc.target/s390/vector/long-double-asm-commutative.c:11:3: error: output constraint 0 must specify a single register 11 | asm("lxr\t%0,%1\n" | ^~~ during RTL pass: stack gcc/testsuite/gcc.target/s390/vector/long-double-asm-commutative.c:16:1: internal compiler error: in replace_reg, at reg-stack.c:714 16 | } | ^ 0x6b654d replace_reg /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:714 0xd6e91b compare_for_stack_reg /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:1379 0xd6e91b subst_stack_regs_pat /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:2001 0xd6f212 subst_stack_regs /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:2444 0xd6f418 convert_regs_1 /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3080 0xd6f418 convert_regs_2 /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3214 0xd704c8 convert_regs /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3249 0xd704c8 reg_to_stack /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3374 0xd704c8 rest_of_handle_stack_regs /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3429 0xd704c8 execute /var/tmp/portage/sys-devel/gcc-11.0.1_alpha20210314/work/gcc-11-20210314/gcc/reg-stack.c:3461