> experimenting with various combinations of values synth.audio-channels and 
> synth.audio-groups either gets me effects on all channels or none

Seems like you created the Ladspa effects on the Main:L and Main:R
ports. Have you tried explicitly specifying the subgroups as described
here?

https://github.com/FluidSynth/fluidsynth/blob/master/doc/ladspa.md#multi-channel-output


Tom

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