OK I've ran Django with psyco and hit it with 50 requests, here are the results:
without psyco: 265822 function calls (207471 primitive calls) in 3.547 CPU seconds with psyco: 66865 function calls (63420 primitive calls) in 1.457 CPU seconds So basically - if you want a quick Django - use psyco :) Next thing I'm going to do is experiment with the more precise template caching which Adrian propoesd but I bet that doesn't give as impressive results as psyco did.