I'll add that I've got the same issue; the settings slider has no effect on the mouse speed (ThinkPad USB Laser Mouse).
I solved it by removing the following package (NOT RECOMMENDED, MAY BREAK YOUR SYSTEM): xserver-xorg-input-libinput This introduced a new issue described here: https://askubuntu.com/questions/904707/sound-indicator-system-slider- jumps-in-steps-of-10 -- You received this bug notification because you are a member of Desktop Packages, which is subscribed to xinput in Ubuntu. https://bugs.launchpad.net/bugs/1682193 Title: Mouse acceleration significantly reduced after upgrade to 17.04 Status in xinput package in Ubuntu: Confirmed Bug description: My external Logitech USB mouse was behaving nicely under 16.10 but after upgrade to 17.04 it has slowed down to a crawl. Settings slidebars are set at the maximum acceleration, but it only affects the touch pad, the mouse is extremely slow. To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/xinput/+bug/1682193/+subscriptions -- Mailing list: https://launchpad.net/~desktop-packages Post to : desktop-packages@lists.launchpad.net Unsubscribe : https://launchpad.net/~desktop-packages More help : https://help.launchpad.net/ListHelp