>From what I can tell, _LARGEFILE_SOURCE only seems to provide prototypes for fseeko() and ftello(). I assume Sam means building such that off_t is 64 bits, which I think requires defining _FILE_OFFSET_BITS=64.
off_t doesn't appear in any public krb5 header file, so there shouldn't be any direct ABI impact from building with 64-bit off_t. There is one instance of FILE * in gssrpc/xdr.h. Do those interoperate between the _FILE_OFFSET_BITS=64 universe and the regular universe?