Just uploaded a fix in version 0.22-1.1. Here's the patch:
--- gquilt.sh.orig 2010-12-04 03:32:28.629662635 -0600
+++ gquilt.sh 2010-12-04 03:36:23.721772339 -0600
@@ -8,7 +8,7 @@
GQUILT_ICON=$PREFIX/share/pixmaps/gquilt.xpm
export GQUILT_ICON
-PYTHONPATH=$PYTHONPATH:$GQUILT_LIB_DIR
+PYTHONPATH=${PYTHONPATH:+$PYTHONPATH:}$GQUILT_LIB_DIR
export PYTHONPATH
exec python $GQUILT_LIB_DIR/gquilt.py-Steve
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