Hi,

I' having the same issue as the reporter on all of the machines I am responsible for. Also none of the tips in https://wiki.debian.org/Thunderbird#Bug_Reporting_.2F_Issues are helping on any of those machines.
Perhaps I have some additional to be able to identify how to solve this:
I am using only IMAP Accounts. On one PC I tried to setup a new profile. Right after just having configured the first account, the behavior was identical to my existing profile, TB was unresponsive most of the time. In the General-Settings I changed the format to "File per message (maildir)", removed the account and recreated it.
Though the usage ("top") also seems very high, TB "feels" responsive.
What I have not done so far:
 * Added my other accounts
 * Added any Address book (I'm using multiple CardDAV books)
 * Added any Calendar (I'm using multiple CalDAV-Calendars and one
   readonly ICS file)

Therefore I see a chance that converting all mailboxes to maildir format might solve this issue. As a first step, it would be good if someone else could either falsify my assumption or confirm this is also helping in a second scenario. If this can be confirmed, the next step would be to "migrate" accounts from mbox to maildir format. The main problem I see is, that I don't know a way to convert an existing account in TB from mbox to maildir format. I read something about an experimental setting (mail.store_conversion_enabled) but I have no experience with this (yet?).

Regards
Armin

P.S.: Having to convert all profiles on all machines manually is not acceptable, I don't even want to estimate how long this might take.

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