How about dropping smuxi-frontend-gnome entirely? It has a low enough popcon. Upstream does not seem to move towards gtk3 anytime soon.
- Bug#967750: smuxi: depends on deprecated GTK 2 Bastian Germann
- Bug#967750: smuxi: depends on deprecated GTK 2 Bastian Germann
- Bug#967750: smuxi: depends on deprecated GTK 2 Bastian Germann
- Bug#967750: smuxi: depends on deprecated GTK ... Bastian Germann