After installing the package libgtk-3-dev
and "pip install python-config"

running "pip install --upgrade wxPython" results in

--gtk3 --python="/usr/bin/python" --out=build/waf/2.7/gtk3 configure build
  Setting top to                           : /tmp/pip-install-nNxPM7/wxPython
  Setting out to                           : 
/tmp/pip-install-nNxPM7/wxPython/build/waf/2.7/gtk3
  Checking for 'gcc' (C compiler)          : /usr/bin/gcc
  Checking for 'g++' (C++ compiler)        : /usr/bin/g++
  Checking for program 'python'            : /usr/bin/python
  Checking for python version >= 2.7.0     : 2.7.16
  python-config                            : not found
  Checking for library python2.7 in LIBDIR : not found
  Checking for library python2.7 in python_LIBPL : yes
  Checking for header Python.h                   : Distutils not installed? 
Broken python installation? Get
python-config now!
  The configuration failed
  (complete log in 
/tmp/pip-install-nNxPM7/wxPython/build/waf/2.7/gtk3/config.log)
  Command '"/usr/bin/python" /tmp/pip-install-nNxPM7/wxPython/bin/waf-2.0.19
--wx_config=/tmp/pip-install-nNxPM7/wxPython/build/wxbld/gtk3/wx-config --gtk3 
--python="/usr/bin/python"
--out=build/waf/2.7/gtk3 configure build ' failed with exit code 1.
  Finished command: build_py (0.936s)
  Finished command: build (8m26.930s)
  Command '"/usr/bin/python" -u build.py build' failed with exit code 1.
 
  ----------------------------------------
  Failed building wheel for wxPython

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