We (upstream) have just released Biopython 1.76 which thanks to the Debian team's feedback from 1.75 should be less problematic on alternative CPUs:
https://www.open-bio.org/2019/12/20/biopython-1-76-released/ https://pypi.python.org/pypi/biopython/1.76 These are the commits which I think you might want to consider back-porting for the Biopython 1.75 package if there are still problems with the Debian tests: https://github.com/biopython/biopython/commit/4045706f7ccb4a55421071fbfa7a9bdc242c4004 https://github.com/biopython/biopython/commit/8ebe305a6bfd8efd7470b8dd2c49d20d046f6196 https://github.com/biopython/biopython/commit/f82deab3f37739ffe1811a96bc30c0d73d1f14b5 Michael Crusoe has assisted in getting ARM64 etc included as part of our usual TravisCI testing (although they do sometimes timeout), which hopefully will stop this particular problem reoccurring. Thank you all, Peter