Disclaimer: I'm not (this or any package) maintainer, TMMV.
There are a number of architecture-dependent #ifdef's in the code (AARCH64 in 1.1.0, __i386__ || __amd64__ in git master), so I think that running foreign-arch irqbalance can be unsafe (well, I guess only practical case when someone would want to run foreign-arch irqbalance is amd64/i386/x32, and /this/ combination seems not affected; unfortunately, as there are no way "partially enable m-a foreign on subset of architectures", it is still no go).